7T GRE Enables Detection of Subiculum Iron Deposits in AD

Abnormal accumulation of iron has been found in the subiculum of Alzheimer’s Disease (AD) patients postmortem. This motivated us to push MRI resolution to observe iron accumulation in vivo in AD patients. Using optical prospective motion correction to enable higher resolution at 7T, we imaged 4 healthy controls, 3 mild cognitive impairment, and 1 Alzheimer’s Disease patient with a 60-minute research brain MRI protocol. Hippocampal iron deposits were detected by a neuroradiologist aware of diagnosis in 2 out of 4 MCI/AD subjects despite that mean R2* quantification in the subiculum was not significantly different between healthy control and MCI/AD subjects.