September 11, 2025

Diagnostic Performance of Prothrombin Time and Activated Partial Thromboplastin Time in Children: A Service Evaluation.

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Discussion

Evaluation shows significant abnormal results in coagulation tests among children, highlighting potential for improved diagnosis.

Abnormal coagulation profiles were found in 17.0% of valid requests for PT and aPTT, suggesting diagnostic challenges.
Youden's index identified aPTT > 31.4 s as clinically significant for inherited bleeding disorders with AUC > 0.8.
During the evaluation, 15.7% of samples were rejected, indicating room for better laboratory management and re-testing protocols.
The study emphasizes the importance of refining coagulation screening practices in paediatrics to address abnormal results more effectively.

Gurumurthy et al. (2025) studied this question.

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