What type of study is this?

September 14, 2025

Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases.

View Full Paper

Ask AI

Bookmark

Authors

This research identifies inhibitors that block GTP binding in K-Ras and other small GTPases, suggesting therapeutic potential in cancer.

Significantly lower binding affinities for GTP in K-Ras were identified, providing new insights into druggable targets.
Over 400 small molecules were discovered that can compete with GTP for binding to K-Ras and its mutants.
Two specific inhibitors were shown to affect signaling and proliferation in cancer cells with K-Ras mutations.
These compounds are poised to serve as novel pan-Ras superfamily inhibitors, impacting other targets like RAB5A and RAB35.

Carta et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark