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Novel copper-catalyzed process generates quaternary stereocenters in spiroindolenines, indicating high selectivity.
We herein report a novel copper-catalyzed asymmetric dearomative [4 + 1] spirocyclization of 3H-indoles with vinyl ethynylethylene carbonates. This transformation proceeds through a highly chemo-, regio-, and enantioselective nucleophilic addition/intramolecular annulation cascade of a reactive copper vinylallenylidene intermediate, delivering a series of valuable spiroindolenine derivatives featuring a chiral quaternary stereocenter with excellent efficiency.
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Guo et al. (2025) studied this question.
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