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This is a Literature Review study.

September 14, 2025

The Immune System and Cellular Senescence: A Complex Interplay in Aging and Disease.

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This review highlights the effects of immunosenescence and cellular senescence on aging, suggesting advances in therapeutic interventions.

Immunosenescence leads to impaired immune responses, contributing to age-related diseases and reduced healthspan.
Key effects of immunosenescence include T-cell dysfunction and chronic inflammation, which worsen with aging.
This review dissects the interplay between the immune system and senescent cells, focusing on recent advancements targeting aging.
Targeting PD-L1 may restore immune function, offering potential routes for promoting healthier aging and longevity.

Ayoub et al. (2025) studied this question.

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This review highlights the effects of immunosenescence and cellular senescence on aging, suggesting advances in therapeutic interventions.