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Subchronic oral toxicity of clodinafop-propargyl in rats: toxic effects in liver, kidney, and spleen and NOAEL gender differences

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This subchronic toxicity study reveals impacts on liver, kidney, and spleen in rats, suggesting gender-based differences in NOAEL.

Male rats demonstrated heightened sensitivity to clodinafop-propargyl, with hepatotoxic effects evident.
Female rats at high doses showed abnormal AST levels and a significant incidence of hepatocellular hypertrophy.
NOAEL was established at 24.0 mg/kg/d for females and 7.8 mg/kg/d for males, indicating varying toxicity levels.
Long-term exposure assumed to damage liver, kidney, and spleen, emphasizing the importance of gender differences in safety assessments.

Zhu et al. (2025) studied this question.

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