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September 10, 2025

Study on subacute toxicity of p-chloro-m-xylenol in rats.

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Observational study shows toxic effects on hematological metrics in male and female Wistar rats, highlighting kidney vulnerability.

p-chloro-m-xylenol exhibits significant toxic effects on the blood system in rats after 30 days of exposure.
In female rats at 45.00 mg/kg·BW, kidney weight decreased significantly from 1.71 g to 1.59 g compared to controls (P<0.05).
After treatment, male rats at 11.25 mg/kg·BW showed lower monocyte percentage (4.81%) versus the control (5.86%).
The study points to potential kidney toxicity as a significant concern following exposure to p-chloro-m-xylenol.

Li et al. (2025) studied this question.

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