What question did this study set out to answer?

The aim is to evaluate the acute and subacute oral toxicities of a chloroform extract from Pseudomonas fluorescens DS17R in Wistar rats.

April 26, 2026Journal of ToxicologyOpen Access

Safety Assessment of Pseudomonas fluorescens DS17R Chloroform Extract: Low Acute But Dose‐Dependent Subacute Oral Toxicity in Rats

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Authors

SMSamuel Arsène Ntyam MendoUniversité de Yaoundé I SNSéverin Tchameni NguemeziUniversity of Douala LMLaure Brigitte Kouitcheu MabekuUniversité de Yaoundé I

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Implication

Randomized trial evaluates oral toxicity of Pseudomonas fluorescens DS17R chloroform extract in rats, indicating potential safe use as a biocontrol agent.

Key Points

The aim is to evaluate the acute and subacute oral toxicities of a chloroform extract from Pseudomonas fluorescens DS17R in Wistar rats.
Acute toxicity tested with doses of 300, 2000, and 5000 mg/kg body weight (n=3 per dose); observed for 14 days.
Subacute toxicity assessed with daily doses of 0, 57.5, 115, 230, and 460 mg/kg body weight for 28 days (n=5 per group); hematological, biochemical, and histopathological analyses performed.
50% mortality observed at 5000 mg/kg body weight; estimated median lethal dose (LD50) is 4574 mg/kg, classifying as practically nontoxic.
Subacute exposure showed body weight reductions at doses ≥115 mg/kg and hepatic enlargement at 115–460 mg/kg; biochemical changes included elevated alkaline phosphatase and mild AST increase.
Signs of renal stress, hematopoietic and immune modulation were noted at various doses, indicating adaptive metabolic responses without irreversible damage.

Cite This Study

Mendo et al. (2026) studied this question.

synapsesocial.com/papers/69edacbd4a46254e215b4689 https://doi.org/10.1155/jt/8893441

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Implication

Randomized trial evaluates oral toxicity of Pseudomonas fluorescens DS17R chloroform extract in rats, indicating potential safe use as a biocontrol agent.

Safety Assessment of Pseudomonas fluorescens DS17R Chloroform Extract: Low Acute But Dose‐Dependent Subacute Oral Toxicity in Rats

Discussion

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Implication

Key Points

Cite This Study

Safety Assessment of Pseudomonas fluorescens DS17R Chloroform Extract: Low Acute But Dose‐Dependent Subacute Oral Toxicity in Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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