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September 16, 2025

Design, Synthesis, and Antibacterial Activity Evaluation and Mechanism of 1-

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Authors

GWGuiyun WuMYMengzhi YangTHTian Huang

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Overview

Antibacterial compounds exhibit moderate activity against specific bacteria, suggesting novel mechanisms for treatment.

Key Points

  • Compound P16 demonstrated potent antibacterial activity against Xanthomonas oryzae with an EC50 of 2.54 μg/mL.
  • This compound also exhibited protective efficacy of 86.41% against Xoo, indicating its potential for practical use.
  • Assessment using 3-pyrazolylindole derivatives revealed significant impacts on biofilm and bacterial motility.
  • Findings call for more research on compound P16 as a lead candidate against rice and citrus bacterial diseases.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68c93fe601120bef803bb0bahttps://doi.org/10.1021/acs.jafc.5c02341
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