What question did this study set out to answer?

To synthesize novel dithiocarbamate-containing 4H-chromen-4-one derivatives and evaluate their antibacterial efficacy against economically damaging plant bacterial pathogens.

April 24, 2020Journal of Agricultural and Food Chemistry

Antibacterial Activities of Novel Dithiocarbamate-Containing 4H-Chromen-4-one Derivatives

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Authors

SJShichun Jiang SSShijun Su MCMei Chen

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Overview

Laboratory evaluation demonstrates strong antibacterial activity of novel dithiocarbamate-chromenone derivatives against plant pathogens, highlighting their potential as agricultural bactericides.

Key Points

To synthesize novel dithiocarbamate-containing 4H-chromen-4-one derivatives and evaluate their antibacterial efficacy against economically damaging plant bacterial pathogens.
Synthesized a series of novel dithiocarbamate-containing 4H-chromen-4-one derivatives.
Assayed antibacterial activity in vitro against Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri, benchmarking against thiodiazole copper and bismerthiazol.
Investigated mode of action via scanning electron microscopy on bacterial cell membranes and evaluated in vivo efficacy and defensive enzyme activities.
Compound E6 demonstrated the most potent in vitro activity against X. axonopodis pv. citri with an EC50 of 0.11 μg/mL, compared to 59.97 μg/mL for thiodiazole copper and 48.93 μg/mL for bismerthiazol.
Compound E14 showed the highest in vitro activity against X. oryzae pv. oryzae with an EC50 of 1.58 μg/mL, compared to 83.04 μg/mL for thiodiazole copper and 56.05 μg/mL for bismerthiazol.
Scanning electron microscopy revealed that compounds E6 and E14 caused rupture or deformation of bacterial cell membranes, while in vivo assays showed E14 reduced X. oryzae pv. oryzae infection more effectively than both control agents.

Cite This Study

Jiang et al. (2020) studied this question.

synapsesocial.com/papers/6aacfbd4f18f9990ee1e6227 https://doi.org/10.1021/acs.jafc.0c01652

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April 24, 2020Journal of Agricultural and Food Chemistry

Antibacterial Activities of Novel Dithiocarbamate-Containing 4H-Chromen-4-one Derivatives

View Full Paper

Ask AI

Bookmark

Authors

SJShichun Jiang SSShijun Su MCMei Chen

Discussion

Member takes

Overview

Laboratory evaluation demonstrates strong antibacterial activity of novel dithiocarbamate-chromenone derivatives against plant pathogens, highlighting their potential as agricultural bactericides.

Key Points

To synthesize novel dithiocarbamate-containing 4H-chromen-4-one derivatives and evaluate their antibacterial efficacy against economically damaging plant bacterial pathogens.
Synthesized a series of novel dithiocarbamate-containing 4H-chromen-4-one derivatives.
Assayed antibacterial activity in vitro against Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri, benchmarking against thiodiazole copper and bismerthiazol.
Investigated mode of action via scanning electron microscopy on bacterial cell membranes and evaluated in vivo efficacy and defensive enzyme activities.
Compound E6 demonstrated the most potent in vitro activity against X. axonopodis pv. citri with an EC50 of 0.11 μg/mL, compared to 59.97 μg/mL for thiodiazole copper and 48.93 μg/mL for bismerthiazol.
Compound E14 showed the highest in vitro activity against X. oryzae pv. oryzae with an EC50 of 1.58 μg/mL, compared to 83.04 μg/mL for thiodiazole copper and 56.05 μg/mL for bismerthiazol.
Scanning electron microscopy revealed that compounds E6 and E14 caused rupture or deformation of bacterial cell membranes, while in vivo assays showed E14 reduced X. oryzae pv. oryzae infection more effectively than both control agents.

Cite This Study

Jiang et al. (2020) studied this question.

synapsesocial.com/papers/6aacfbd4f18f9990ee1e6227 https://doi.org/10.1021/acs.jafc.0c01652

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