What question did this study set out to answer?

To synthesize novel benzimidazole-containing flavonoid derivatives and evaluate their antibacterial and antiviral potencies alongside their mechanism of action against plant pathogens.

January 9, 2021Journal of Saudi Chemical SocietyOpen Access

Antibacterial and antiviral activities and action mechanism of flavonoid derivatives with a benzimidazole moiety

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To synthesize novel benzimidazole-containing flavonoid derivatives and evaluate their antibacterial and antiviral potencies alongside their mechanism of action against plant pathogens.
Synthesized a series of flavonoid derivatives modified with a benzimidazole moiety.
Tested in vitro antibacterial inhibition against Xanthomonas axonopodis pv. citri (Xac), Ralstonia solanacearum (Rs), and Xanthomonas oryzae pv. oryzae (Xoo), analyzing bacterial surface disruption via scanning electron microscopy (SEM).
Evaluated curative, protective, and inactivating antiviral activities against tobacco mosaic virus (TMV) and quantified binding affinity to TMV coat protein using microscale thermophoresis (MST).
Compound 4e displayed potent antibacterial activity against Rs with an EC50 of 14.5 µg/mL, outperforming thiodiazole-copper (EC50 118.9 µg/mL), bismerthiazol (EC50 55.1 µg/mL), and myricetin (EC50 82.3 µg/mL).
At 500 µg/mL, compound 4n produced curative, protective, and inactivating activities of 54.1%, 57.6%, and 75.3% against TMV, comparable to or exceeding ningnanmycin (49.0%, 55.8%, and 82.7%, respectively).
MST analysis revealed that compound 4n bound to the TMV coat protein with a dissociation constant (Kd) of 1.049 ± 0.582 µmol/L, exceeding ningnanmycin (Kd 1.058 ± 0.286 µmol/L).

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Implication

Experimental study reveals potent antibacterial and antiviral activities of benzimidazole-flavonoid hybrids against plant pathogens, suggesting high potential as crop-protection agents.

Cite This Study

Chen et al. (2021) studied this question.

synapsesocial.com/papers/6a74fb5f5be14952a7f54b6b https://doi.org/10.1016/j.jscs.2020.101194

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Implication

Experimental study reveals potent antibacterial and antiviral activities of benzimidazole-flavonoid hybrids against plant pathogens, suggesting high potential as crop-protection agents.

Antibacterial and antiviral activities and action mechanism of flavonoid derivatives with a benzimidazole moiety

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Discussion

Implication

Cite This Study

Antibacterial and antiviral activities and action mechanism of flavonoid derivatives with a benzimidazole moiety

Key Points

Discussion

Implication

Cite This Study

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