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September 16, 2025

Impact of Glycoclustering on Stiffening of MUC5AC Peptides Revealed by High-Efficiency Synthesis.

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Authors

AGArseniy E. GalashovEGElisabetta Di GregorioPPPolina Ponomareva

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Overview

Automated solid-phase synthesis demonstrated stiffening of MUC5AC peptides, suggesting glycosylation impacts structure.

Key Points

  • Glycosylation significantly stiffens the MUC5AC peptide backbone as observed through spectroscopy techniques.
  • Peptides with up to 30 GalNAc residues were synthesized, marking a substantial achievement in peptide engineering.
  • The method utilizes a DMF-free solid-phase synthesis approach, enhancing the efficiency of producing glycosylated peptides.
  • This research highlights the role of glycoclustering in altering peptide conformations and rigidity.

Cite This Study

Galashov et al. (2025) studied this question.

synapsesocial.com/papers/68c93fe601120bef803bb0edhttps://doi.org/10.1002/anie.202508278
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