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September 30, 2025Angewandte Chemie

Impact of Glycoclustering on Stiffening of MUC5AC Peptides Revealed by High‐Efficiency Synthesis

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The study demonstrates stiffening of MUC5AC peptides through glycosylation in peptides, suggesting structural implications.

Glycosylation of MUC5AC peptides significantly increases stiffness, indicating a structural transformation.
Peptides with up to 30 GalNAc residues showcased improved synthesis methods, achieving 100% occupancy of glycosylation sites.
Automated synthesis involving diselenide–selenoester ligation enabled efficient glycoeconomic synthesis of complex peptides.
The findings reveal structural shifts in peptide conformation, suggesting deeper implications for mucin biology and function.

Galashov et al. (2025) studied this question.

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September 30, 2025Angewandte Chemie

View Full Paper

Ask AI

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Authors

The study demonstrates stiffening of MUC5AC peptides through glycosylation in peptides, suggesting structural implications.

Glycosylation of MUC5AC peptides significantly increases stiffness, indicating a structural transformation.
Peptides with up to 30 GalNAc residues showcased improved synthesis methods, achieving 100% occupancy of glycosylation sites.
Automated synthesis involving diselenide–selenoester ligation enabled efficient glycoeconomic synthesis of complex peptides.
The findings reveal structural shifts in peptide conformation, suggesting deeper implications for mucin biology and function.

Galashov et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark