New quantitative method improves detection accuracy in reference material for epstein-barr virus monitoring.
Epstein-Barr virus (EBV) is a distinct viral agent associated with a broad spectrum of diseases and has infected a significant proportion of the global population. Although EBV can remain latent throughout an individual’s lifetime, its reactivation plays a critical role in the pathogenesis of various diseases. A quantitative method was developed and applied to characterize the reference material (RM) containing the Epstein-Barr virus (EBV) genome. The assigned value, including expanded uncertainty, was determined to be (1529 ± 147) copies/μL. Validation studies of commercial kits revealed inconsistent performance levels, which may contribute to inaccurate diagnosis of EBV-related diseases. The integration of the quantitative method with the RM is anticipated to improve the accuracy and reliability of EBV detection and monitoring.
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LIU et al. (2025) studied this question.
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