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This is a Cross-Sectional Study study.

September 12, 2025ERJ Open ResearchOpen Access

Targeted and whole genome sequencing for drug resistance and genetic relatedness inference of rifampicin resistant Mycobacterium tuberculosis – an in-depth comparison

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Cross-sectional analysis compares drug resistance and genetic relatedness in rifampicin-resistant TB using WGS and tNGS.

Drug resistance inference was highly concordant between targeted ngs and whole genome sequencing at ≥92% for most drugs.
tNGS detected more minor variants than WGS, identifying 76 versus 32 respectively, indicating greater sensitivity.
WGS provided comprehensive lineage and sub-lineage information for all samples, while tNGS reported lineage for only 67%.
Further research is needed to ascertain the clinical significance of minor variants in drug-resistant tuberculosis.

Fuertes et al. (2025) studied this question.

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September 12, 2025ERJ Open ResearchOpen Access

View Full Paper

Ask AI

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Authors

Cross-sectional analysis compares drug resistance and genetic relatedness in rifampicin-resistant TB using WGS and tNGS.

Drug resistance inference was highly concordant between targeted ngs and whole genome sequencing at ≥92% for most drugs.
tNGS detected more minor variants than WGS, identifying 76 versus 32 respectively, indicating greater sensitivity.
WGS provided comprehensive lineage and sub-lineage information for all samples, while tNGS reported lineage for only 67%.
Further research is needed to ascertain the clinical significance of minor variants in drug-resistant tuberculosis.

Fuertes et al. (2025) studied this question.

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