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September 12, 2025Journal of Clinical MedicineOpen Access

Dual Impacts of Lung Transplantation on the Recovery and Comorbidity of Interstitial Lung Diseases: A Longitudinal Assessment of the Benefits and Burden

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Authors

SKStefan KuhnertLWLee G. WilkeJSJanine Sommerlad

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Overview

Longitudinal analysis reveals benefits of lung transplantation on lung function and exercise, highlighting rising comorbidity risks.

Key Points

  • Lung transplantation significantly improves pulmonary function, exercise capacity, and hemodynamics in patients with interstitial lung disease.
  • Patients experienced marked post-transplant improvements, with FVC and DLCO increasing by approximately 38% and 43%, respectively.
  • Despite significant gains in lung function, there was a notable decline in renal function and increased comorbidity burden reflected by the Comorbidity-Polypharmacy Score.
  • Dynamic risk management is essential to balance the substantial benefits of lung transplantation against the rising challenges of comorbid conditions.

Cite This Study

Kuhnert et al. (2025) studied this question.

synapsesocial.com/papers/68d44a4031b076d99fa537bchttps://doi.org/10.3390/jcm14186420
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Retrospective analysis of patients with interstitial lung disease on lung-transplantation waiting-list2014
  2. 2Expanding Remote Patient Monitoring for Pre‐Lung Transplant Candidates With Interstitial Lung Disease2026
  3. 3Improvements in Patient-Reported Functioning after Lung Transplant is Associated with Improved Quality of Life and Survival2024
  4. 4Contribution of host-related immune factors to frequency and severity of infections in lung transplant recipients.2026
  5. 5Exercise Limitation in Recipients of Lung Transplants2004 · 51 citations