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September 12, 2025LeukemiaOpen Access

Acute myeloid leukaemia cells express high levels of androgen receptor but do not depend on androgen signaling for survival

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Authors

FMFarideh Miraki‐MoudLALinda Ariza‐McNaughtonTKThinzar Koko

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Overview

Analysis finds androgen receptor overexpression in acute myeloid leukaemia cells, yet androgen signaling does not enhance survival outcomes.

Key Points

  • High levels of androgen receptor were found in acute myeloid leukaemia cells, but this does not improve survival.
  • Men with acute myeloid leukaemia showed a significantly lower remission rate compared to women, highlighting a sex-based survival difference.
  • Analysis involved 4281 patients from the AML17 and AML19 trials, revealing key insights into the role of androgen receptor in AML.
  • Targeting androgen signaling may not be effective in improving outcomes for men with acute myeloid leukaemia.

Cite This Study

Miraki‐Moud et al. (2025) studied this question.

synapsesocial.com/papers/68d44a4031b076d99fa53adchttps://doi.org/10.1038/s41375-025-02752-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Androgen receptor signaling as a new target for intervention in acute myeloid leukemia2025
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  4. 4Abstract 4856: Sex differences in childhood leukemia genomics2024
  5. 5Analysis of the androgen response of 23 patients with agnogenic myeloid metaplasia: The value of chromosomal studies in predicting response and survival1982 · 108 citations