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September 28, 2025Blood AdvancesOpen Access

Androgen receptor signaling as a new target for intervention in acute myeloid leukemia

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Authors

FQFenghua QianDSDeborpita SarkarBABrooke E. Arner

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Overview

Observational analysis revealed high androgen receptor levels worsen acute myeloid leukemia in models, suggesting new anti-androgen therapies may enhance treatment efficacy.

Key Points

  • High androgen receptor expression in leukemia initiating cells leads to more severe acute myeloid leukemia, especially in females, and thus highlights a potential therapeutic target.
  • ARN509 and finasteride therapies significantly improved survival in AML mice, demonstrating the effectiveness of repurposing prostate cancer drugs for leukemia treatment.
  • Using a murine model, it was shown that AR signaling mechanisms differ between sexes, with females displaying high AR and low ligand levels compared to low AR and high ligand levels in males.
  • The study provides evidence that targeting the androgen receptor pathways may offer new therapeutic options for patients with acute myeloid leukemia, but further research is needed.

Cite This Study

Qian et al. (2025) studied this question.

synapsesocial.com/papers/68d913ab4ddcf71ba560bc0dhttps://doi.org/10.1182/bloodadvances.2024012639
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute myeloid leukaemia cells express high levels of androgen receptor but do not depend on androgen signaling for survival2025
  2. 2Inhibition of the aryl hydrocarbon receptor eliminates leukemia stem cells in murine models of Acute Myeloid Leukemia2025
  3. 3The Aryl Hydrocarbon Receptor Regulates Invasiveness and Motility in Acute Myeloid Leukemia Cells through Expressional Regulation of Non-Muscle Myosin Heavy Chain IIA2024 · 2 citations
  4. 4The aryl hydrocarbon receptor is associated with monocytic AML and innate immune resistance reversible with an AHR inhibitor2025
  5. 5517 Dual roles of β2-adrenergic signaling in the progression of acute myeloid leukemia2026