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December 8, 2025BloodOpen Access

Inhibition of the aryl hydrocarbon receptor eliminates leukemia stem cells in murine models of Acute Myeloid Leukemia

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Authors

RDRhea DesaiPBPeter BrowettPKPurvi M. Kakadia

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Overview

Inhibition of the aryl hydrocarbon receptor reduces leukemia stem cells in murine AML, suggesting new strategies for cancer treatment.

Key Points

  • This research aims to assess the effects of aryl hydrocarbon receptor inhibition on leukemia stem cells in acute myeloid leukemia.
  • Utilized murine bone marrow transplantation models of AML
  • Applied AHR agonist ITE and antagonist CH-223191 to LSCs ex vivo
  • Performed limiting dilution assays to measure LSC frequency in treated cells
  • Evaluated effects on healthy hematopoietic stem cells using a competitive repopulation assay
  • LSC frequency reduced significantly after CH-223191 treatment in both AML models
  • No leukemia developed in mice transplanted with AHR antagonist-treated LSCs
  • Healthy HSCs showed no negative effects from AHR inhibition, promoting hematopoiesis

Cite This Study

Desai et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e149https://doi.org/10.1182/blood-2025-6101
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The aryl hydrocarbon receptor is associated with monocytic AML and innate immune resistance reversible with an AHR inhibitor2025
  2. 2The Aryl Hydrocarbon Receptor Regulates Invasiveness and Motility in Acute Myeloid Leukemia Cells through Expressional Regulation of Non-Muscle Myosin Heavy Chain IIA2024 · 2 citations
  3. 3Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapy2025 · 2 citations
  4. 4CⅡTA-mediated up-regulation of MHC reverses immune evasion of leukemia stem cells in refractory/relapsed AML2025
  5. 5Abstract 4537: Modified acetate salt form of GHRH-antagonist retains anti-leukemic activity against acute myelogenous leukemia2026 · 1 citations