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September 12, 2025Annals of HematologyOpen Access

Multicenter, real-world observational study of AVA therapy following ELT/HET switching in Chinese children with persistent/chronic primary ITP

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Authors

JLJingjing LiuZWZhifa WangNWNan Wang

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Overview

Cohort study reports AVA therapy's efficacy in pediatric ITP following ELT or HET transitions, suggesting improved outcomes.

Key Points

  • AVA therapy resulted in a sustained response rate of 48.4% in patients switched from ELT, improving their condition.
  • Among patients switched from HET, the sustained response rate was 33.3%, indicating a notable treatment effect.
  • The study involved 55 pediatric ITP patients, highlighting the complexities of treatment-switching strategies using TPO-RAs.
  • AVA therapy effectively reduced bleeding and ITP medication use, contributing to a lower treatment burden with manageable side effects.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d44b2a31b076d99fa545cahttps://doi.org/10.1007/s00277-025-06567-9
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