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September 10, 2025Frontiers in MedicineOpen Access

Analysis of the efficacy of avatrombopag for the delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation for aplastic anemia

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Authors

XZXinhe ZhangJFJia FengZTZhengwei Tan

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Overview

Observational analysis reveals early avatrombopag improves platelet engraftment in aplastic anemia, indicating better patient outcomes.

Key Points

  • Early transition to avatrombopag led to a higher overall survival rate at 1 year compared to rh-TPO.
  • The complete remission rate significantly favored the avatrombopag group at 3 and 6 months post-transplant.
  • Platelet engraftment was achieved more quickly with avatrombopag, leading to fewer transfusion needs.
  • This approach potentially enhances survival rates and overall outcomes for high-risk aplastic anemia patients.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c1c63e54b1d3bfb60f25ffhttps://doi.org/10.3389/fmed.2025.1626325
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of avatrombopag in the treatment of thrombocytopenia after umbilical cord blood transplantation2024 · 1 citations
  2. 2Avatrombopag improves platelet engraftment after haploidentical hematopoietic stem cell transplantation: A randomized, double-blind, multicenter, placebo-controlled trial2025
  3. 3Avatrombopag Reduces Platelet Transfusion Requirement in Thrombocytopenia Subsequent to Antineoplastic Therapies in Haematological Patients: The Experience of a Tertiary Centre2026
  4. 4Avatrombopag for post‐transplant thrombocytopenia following allogeneic haematopoietic stem cell transplantation: A single‐centre retrospective study2026 · 1 citations
  5. 5Multicenter, real-world observational study of AVA therapy following ELT/HET switching in Chinese children with persistent/chronic primary ITP2025 · 2 citations