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December 8, 2025BloodOpen Access

Avatrombopag improves platelet engraftment after haploidentical hematopoietic stem cell transplantation: A randomized, double-blind, multicenter, placebo-controlled trial

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Authors

FWFeng‐Rong WangAnhui UniversityJKJun KongPeking UniversityYCYao ChenHebei Medical University

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Implication

Randomized trial demonstrates improved platelet engraftment in patients undergoing haploidentical HSCT, suggesting avatrombopag enhances safety and efficacy.

Key Points

  • To investigate the safety and efficacy of avatrombopag in enhancing platelet recovery after haplo-HSCT.
  • Conducted a randomized, double-blind, multicenter, placebo-controlled trial across 10 centers in China.
  • Included patients aged 18–65 who underwent haplo-HSCT, excluding those with specific health conditions.
  • Administered avatrombopag 20 mg/day or placebo starting on Day 7 after haplo-HSCT.
  • Significantly more patients in the avatrombopag group achieved a PLT level ≥50×10⁹/L without transfusion by Day 30 (78.0% vs. 56.0%).
  • Median time to platelet recovery was 13 days for the avatrombopag group and 14 days for controls (P=0.087).
  • No patients experienced grade ≥3 adverse events, with similar results in transfusions and survival rates across groups.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e0cbhttps://doi.org/10.1182/blood-2025-377
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of the efficacy of avatrombopag for the delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation for aplastic anemia2025
  2. 2Avatrombopag for post‐transplant thrombocytopenia following allogeneic haematopoietic stem cell transplantation: A single‐centre retrospective study2026 · 1 citations
  3. 3Efficacy and safety of avatrombopag in the treatment of thrombocytopenia after umbilical cord blood transplantation2024 · 1 citations
  4. 4Real-world use of avatrombopag in patients with chronic liver disease and thrombocytopenia undergoing a procedure2023 · 8 citations
  5. 5Avatrombopag Reduces Platelet Transfusion Requirement in Thrombocytopenia Subsequent to Antineoplastic Therapies in Haematological Patients: The Experience of a Tertiary Centre2026