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September 12, 2025Hypertension

Geometric Aging of the Thoracic Aorta: Insights From 2 Large Cohorts

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Aging is associated with profound geometric changes in the thoracic aorta, including elongation and luminal dilation.
In the UKB normative subset, aging leads to a notable increase in aortic volume by 17.124 mL per decade.
Multivariate linear regression analysis was performed on data from 56,164 UK Biobank and 9,417 Penn Medicine Biobank participants.
Females show less pronounced luminal dilation after menopause and more significant changes in curvature, impacting arterial hemodynamics.

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Analysis quantifies geometric remodeling in the thoracic aorta, revealing significant aging effects and gender differences.

Beeche et al. (2025) studied this question.

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