What is the clinical evidence from this study?

Study design: Observational. Population: Aortic Aging (n=208). Intervention: Female sex vs. Male sex. Primary outcome: Age-related changes in BSA-adjusted aortic diameter and tortuosity across different aortic segments.

What question did this study set out to answer?

The study investigates sex differences in aortic aging, focusing on diameter and tortuosity changes with age.

June 26, 2023Open Access

Women are Prone to Age-Related aortic Stiffness

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Key result

Women experience more significant age-related changes in aortic morphology than men, characterized by a more rapid increase in aortic diameter and significantly greater tortuosity in the descending thoracic aorta.

Why the study?

Aortic morphology changes with age, but sex differences in aortic diameter and tortuosity across different segments and the age spectrum remain to be defined.

Population

208 patients with chest and abdomen contrast CT images

Comparison

Aortic diameter and tortuosity across age groups, stratified by sex

Design

Retrospective study

Authors

ZMZixuan MengFirst Affiliated Hospital of Xi'an Jiaotong University LCLele ChengFirst Affiliated Hospital of Xi'an Jiaotong University WLwenjun LiuFirst Affiliated Hospital of Xi'an Jiaotong University

Discussion

Member takes

Implication

Observational data on sex differences in aortic aging should not yet change practice; leaves open need for prospective validation across segments.

Key Points

The study investigates sex differences in aortic aging, focusing on diameter and tortuosity changes with age.
Retrospective analysis of chest and abdomen contrast CT images from July 2021 to April 2022
Measured aortic diameters and tortuosity using enhanced CT imaging and specialized software
Compared mean values across age groups by sex and examined correlation with age.
208 participants included, with positive correlation of BSA-adjusted aortic diameters with age in both sexes, but larger increases in females.
In individuals aged 60-69 and over 80, males showed larger L1 measurements, while females had greater L3 values over 80.
Females exhibited increased aortic tortuosity across ages, particularly in the descending thoracic region, with males showing higher stiffness until overtaken by females in older age groups.

Study Design

Type

Observational (n=208)

Multicenter

Structured PICO

Population

208 adults (mean age 60.1 years, 43.4% female) free of major cardiovascular risk factors who underwent thoracoabdominal CT imaging to evaluate age- and sex-related changes in aortic morphology.

Outcome

Aortic diameter at five aortic levels and arterial tortuosity of various segments measured using enhanced CT imagingsurrogate

Limitations

Small-scale observational cohort study conducted at a single center, limiting generalizability.
Non-ECG gating contrast CT was used, which did not account for the impact of cardiac contraction and diastole on aortic morphologies.
Some subjects had malignant tumors which may have affected the morphology of the aorta.
Potential unmeasured confounding factors may have influenced the outcomes.

Cite This Study

Meng et al. (2023) conducted an observational in Aortic Aging (n=208). Female sex vs. Male sex was evaluated on Age-related changes in BSA-adjusted aortic diameter and tortuosity across different aortic segments. Women experience more significant age-related changes in aortic morphology than men, characterized by a more rapid increase in aortic diameter and significantly greater tortuosity in the descending thoracic aorta.

synapsesocial.com/papers/6a6213745a5e300a3289cee2 https://doi.org/10.21203/rs.3.rs-3038429/v1

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Implication

Observational data on sex differences in aortic aging should not yet change practice; leaves open need for prospective validation across segments.

Women are Prone to Age-Related aortic Stiffness

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Women are Prone to Age-Related aortic Stiffness

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

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