What question did this study set out to answer?

The aim was to explore how central measures of aortic function change with age and their relationship with established vascular stiffness markers.

January 12, 2010HypertensionOpen Access

Reduced Ascending Aortic Strain and Distensibility

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Population

111 asymptomatic subjects free of overt cardiovascular disease (54 men, age range: 20 to 84 years).

Design

Cross-sectional

Authors

ARAlban RedheuilCardiac Imaging WYWen‐Chung YuElectrophysiology CWColin O. WuCardiac Imaging

Discussion

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Implication

Age-related aortic stiffness changes are segment-specific; leaves open differential marker utility in prospective cardiovascular risk studies.

Key Points

The aim was to explore how central measures of aortic function change with age and their relationship with established vascular stiffness markers.
Measured aortic strain, distensibility, and aortic arch pulse wave velocity via MRI in 111 asymptomatic subjects.
Used ultrasound for carotid distensibility and tonometry for carotid-femoral pulse wave velocity.
Adjusted for gender, body size, and heart rate in analyses.
Ascending aortic distensibility decreased by 13.6±1 kPa(-1)x10(-3) for each decade (R(2)=0.62, P<0.0001).
Aortic strain decreased by 5.3±0.5% for each decade of age (R(2)=0.54, P<0.0001).
Aortic arch pulse wave velocity increased by 1.6±0.13 m/sec for each decade (R(2)=0.60, P<0.0001).

Structured PICO

Population

111 asymptomatic subjects free of overt cardiovascular disease (54 men, age range: 20 to 84 years).

Outcome

Age-related changes of central measures of aortic function (aortic strain, distensibility, and aortic arch pulse wave velocity) compared with carotid distensibility, global carotid-femoral pulse wave velocity, and wave reflectionssurrogate

Ascending aortic distensibility is a highly sensitive marker for subclinical large artery stiffening in younger individuals, whereas aortic arch pulse wave velocity is a better marker in older individuals.

Cite This Study

Redheuil et al. (2010) studied this question.

synapsesocial.com/papers/69d56d3675589c71d767cffd https://doi.org/10.1161/hypertensionaha.109.141275

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Implication

Age-related aortic stiffness changes are segment-specific; leaves open differential marker utility in prospective cardiovascular risk studies.

Reduced Ascending Aortic Strain and Distensibility

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Reduced Ascending Aortic Strain and Distensibility

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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