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Large-Scale Conformational Analysis Explains G-Quadruplex Topological Landscape

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This analysis uncovers folding preferences and constraints in G-quadruplex structures, suggesting critical factors in topology determination.

G-quadruplexes exhibit significant variation in folding patterns, notably influenced by loop length constraints.
Evaluating nearly 20,000 G4 conformations revealed that 12 topologies are hindered by long-distance propeller loops.
The study systematically explored 128 DNA sequences to evaluate conformational space and folding preferences.
Understanding G-quadruplex topologies may advance rational design in genomic applications, enhancing regulatory mechanisms.

Jurkowski et al. (2025) studied this question.

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View Full Paper

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Authors

This analysis uncovers folding preferences and constraints in G-quadruplex structures, suggesting critical factors in topology determination.

G-quadruplexes exhibit significant variation in folding patterns, notably influenced by loop length constraints.
Evaluating nearly 20,000 G4 conformations revealed that 12 topologies are hindered by long-distance propeller loops.
The study systematically explored 128 DNA sequences to evaluate conformational space and folding preferences.
Understanding G-quadruplex topologies may advance rational design in genomic applications, enhancing regulatory mechanisms.

Jurkowski et al. (2025) studied this question.

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