This method shows efficient formation of C-C and C-N bonds using N-cyanamide alkenes, suggesting potential in medicinal chemistry.
A visible-light-induced cascade annulation of N-cyanamide alkenes with unsaturated α-halogenocarbonyls for the facile synthesis of piperidino-quinazolinone derivatives has been developed. This transformation simultaneously constructs three C-C bonds, one C-N bond, and three cyclic structures through a cascade process involving alkyl radical addition to alkene followed by three radical annulations. The reaction proceeds under mild conditions and demonstrates a high bond-forming efficiency.
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Zhou et al. (2025) studied this question.
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