September 12, 2025Current UrologyOpen Access

Causal relationships between plasma metabolites and prostate cancer: A Mendelian randomization study exploring immune and inflammatory mediators

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Authors

MHMengjun HuangSun Yat-sen University NDNing DongMoffitt Cancer Center TTTongyu TongSun Yat-sen University

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Implication

Mendelian randomization explores associations between plasma metabolites and prostate cancer risk, indicating pathways through inflammatory markers and immune traits.

Key Points

Eight plasma metabolites are significantly linked to prostate cancer risk, indicating their possible causal roles in disease development.
A higher phosphate-to-uridine ratio correlates with reduced prostate cancer risk, while N-acetyl-arginine is associated with an increased risk.
Mendelian randomization was used, involving 1400 metabolites and utilizing inverse variance weighting for robust results on causality.
The identified metabolites may influence prostate cancer risk by modulating inflammatory markers, highlighting potential therapeutic targets.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3831b076d99fa54ddf https://doi.org/10.1097/cu9.0000000000000307

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Implication

Mendelian randomization explores associations between plasma metabolites and prostate cancer risk, indicating pathways through inflammatory markers and immune traits.

Causal relationships between plasma metabolites and prostate cancer: A Mendelian randomization study exploring immune and inflammatory mediators

Discussion

Member takes

Implication

Key Points

Cite This Study

Causal relationships between plasma metabolites and prostate cancer: A Mendelian randomization study exploring immune and inflammatory mediators

Discussion

Member takes

Implication

Key Points

Cite This Study

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