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September 12, 2025Journal of EthnopharmacologyOpen Access

Study on the Mechanism of Huoxue Jiedu Decoction in the Intervention of Phosphatidylinositol 3-kinase/Serine-threonine kinase/Nuclear factor-kappa B Pathway in the treatment of Deep Vein Thrombosis

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Authors

YWYingrui WangZLZheng LiuYLYuhuan Li

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Overview

Animal studies demonstrate that Huoxue Jiedu Decoction regulates the inflammatory signaling pathway in DVT, suggesting its clinical potential.

Key Points

  • HXJDT significantly ameliorated deep vein thrombosis by inhibiting the inflammatory signaling pathway.
  • The PI3K/Akt/NF-κB pathway was highly expressed in the DVT model, promoting macrophage recruitment and inflammation.
  • The study employed a DVT model and various assays, revealing the molecular mechanisms involved in thrombus formation.
  • These findings highlight the potential of ethnomedicine, like HXJDT, in developing antithrombotic therapies.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d44c3431b076d99fa553fdhttps://doi.org/10.1016/j.jep.2025.120605
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Huo-Xue-Xiao-Zhong Decoction prevents thrombus formation of deep vein thrombosis by targeting SOAT2 to modulate the AKT and ERK pathways2026
  2. 2Network pharmacology-based analysis of the antithrombotic clinical efficacy and antithrombotic mechanism of Huoxue Jiedu prescription in the treatment of polycythemia vera with heat toxin and blood stasis syndrome.2025
  3. 3Integrated metabolomics and network pharmacology leveraging UPLC-Q-TOF-MS reveal material basis and metabolic mechanisms underlying Tongqiao Huoxue Decoction's efficacy in cerebral infarction.2026
  4. 4Yangyinghuoxue decoction exerts a treatment effect on hepatic fibrosis by PI3K/AKT pathway in rat model: based on the network pharmacology and molecular docking2024 · 1 citations
  5. 5Jiedu Huoxue decoction inhibits cardiomyocyte apoptosis via PTEN/AKT/GSK3β-mediated mitochondrial dynamics in myocardial infarction: an integrative study of network pharmacology, transcriptomics and molecular docking2026