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June 10, 2026Journal of EthnopharmacologyOpen Access

Huo-Xue-Xiao-Zhong Decoction prevents thrombus formation of deep vein thrombosis by targeting SOAT2 to modulate the AKT and ERK pathways

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Key result

Huo-Xue-Xiao-Zhong Decoction reduces thrombus burden and endothelial dysfunction by downregulating SOAT2 and suppressing AKT-ERK.

Why the study?

Huo-Xue-Xiao-Zhong Decoction prevents deep vein thrombosis in clinical trials, but the underlying molecular mechanisms remain to be elucidated.

Does Huo-Xue-Xiao-Zhong Decoction prevent thrombus formation in preclinical models of deep vein thrombosis?

Population

Mouse model of DVT (n=8 per group) and TNF-α-induced HUVEC injury model

Comparison

HXXZ treatment vs control models

Design

Preclinical in vivo and in vitro mechanistic study

Authors

JLJizheng LiLYLijuan YangRWRongyi Wang

Discussion

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Member takes

Overview

Animal findings support mechanistic exploration of HXXZ in DVT; leaves open clinical translation pending human trials.

Key Points

  • This study aims to explore the molecular mechanisms by which Huo-Xue-Xiao-Zhong Decoction (HXXZ) prevents thrombus formation in deep vein thrombosis (DVT).
  • Characterized HXXZ using HPLC-Q-TOF-MS.
  • Evaluated efficacy in a DVT mouse model (n=8 per group) and a TNF-α-induced HUVEC injury model.
  • Used network pharmacology, molecular docking, and transcriptomic analysis to identify HXXZ targets.
  • HXXZ treatment significantly reduced thrombus length and mass in vivo, modulating inflammatory and coagulation markers.
  • In vitro, HXXZ lowered cholesterol levels and attenuated apoptosis in TNF-α-injured HUVECs.
  • Transcriptomic analysis identified SOAT2 as a key target, where its knockdown enhanced HXXZ protective effects.

Structured PICO

Does Huo-Xue-Xiao-Zhong Decoction prevent thrombus formation in preclinical models of deep vein thrombosis?

P
Population
Mouse model of DVT (n=8 per group) and TNF-α-induced human umbilical vein endothelial cell injury model.
I
Intervention
Huo-Xue-Xiao-Zhong Decoction (HXXZ)
C
Comparator
Control (implied in preclinical model)
O
Outcome
Thrombus length and mass, and levels of inflammation-related, coagulation-related, and endothelial injury markerssurrogate

Huo-Xue-Xiao-Zhong Decoction prevents thrombus formation in DVT models by targeting SOAT2 and modulating the AKT and ERK pathways.

Cite This Study

Li et al. (2026) studied Deep vein thrombosis. Huo-Xue-Xiao-Zhong Decoction (HXXZ) was evaluated on Thrombus length and mass. Huo-Xue-Xiao-Zhong Decoction significantly reduced thrombus length and mass in vivo and attenuated endothelial dysfunction in vitro by downregulating SOAT2 and suppressing the AKT-ERK pathway.

synapsesocial.com/papers/6a28fe326f82f25be989b8d5https://doi.org/10.1016/j.jep.2026.121973
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