Randomized, double-blind study found dexamethasone and lignocaine reduced pain from propofol in patients, suggesting effective combinations could enhance patient comfort.
Injection of propofol may provoke pain in up to 70 percent of the patients. In this randomized, double-blind study, the effects of lignocaine, dexamethasone and a combination of both on propofol-induced pain were evaluated in 90 surgical patients. The highest incidence of pain found was in the lignocaine group (70%) and the lowest in the combination group (30%). The combined pretreatment also showed significantly reduced mean pain scores (p < 0.01). The combination of lignocaine-dexamethasone was best effective and this might be embraced in reducing propofol-induced pain.
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Baghel et al. (2025) studied this question.
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