Wireless Capsule Device for Targeted and Safe Tissue Biopsy with Integrated Sensing

Tissue biopsy is essential for obtaining samples for diagnosis in gastrointestinal (GI) diseases such as inflammatory bowel disease, ulcers, and cancer. However, conventional endoscopic tools often struggle to access confined and tortuous regions, including the small intestine and upper colon. While capsule devices offer improved navigation to these hard‐to‐reach areas, their biopsy mechanisms carry a relatively high risk of accidental tissue damage. To address this challenge, a magnetically actuated capsule device equipped with a magnetic biopsy unit and an integrated sensing module is proposed for safety‐enhanced biopsy. The magnetic biopsy unit incorporates a foldable linkage and dual magnets that provide a magnetic attraction‐based safety mechanism to prevent unintentional activation during locomotion. The sensing unit, composed of flexible sensors, enables real‐time detection of penetration displacement, allowing for controlled, on‐demand tissue sampling. Retrieving tissues are demonstrated safely from targeted GI tract regions, validating the system's efficacy. A sensor array is also seamlessly integrated to continuously track the capsule's position and orientation, ensuring accurate localization throughout the procedure. Therefore, the proposed sensory capsule device, together with the magnetic actuation and tracking system, offers a promising solution for safe, minimally invasive tissue biopsy in the complex and constrained regions of the GI tract.