A Flexible Wearable Microsystem for Electrochemically Sensing Uric Acid from Sweat

Sweat uric acid (UA) monitoring using wearable electrochemical biosensors is an emerging noninvasive strategy for chronic disease management. However, for current sweat UA biosensors, sweat collection is inefficient, and environmental factors can cause the leakage and degradation of uricase. Herein, this study proposed a new flexible wearable microsystem, integrated with a wireless potentiostat device and a mobile application, for real‐time sweat UA monitoring. A tree‐inspired microfluidic chip is fabricated to collect and transport sweat, and a uricase@FSiO 2 electrochemical sensor is developed to sense sweat UA. Benefiting from hydrophilic FSiO 2 framework modification, the high activity of uricase coated on our sensor is maintained for up to 21 days. The wearable microsystem exhibited efficient sweat collection and excellent UA monitoring performance, with high sensitivity, strong selectivity against interferents, and robust stability. This study provides efficient and cost‐effective strategies for the development of electroanalytical devices for UA monitoring.