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September 12, 2025Bulletin of Russian State Medical UniversityOpen Access

Comparison of the efficacy of mRNA vaccines against M. tuberculosis based on linear and circular RNAs

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Authors

AKAnna KirshinaGSGalina ShepelkovaAKAS Khlebnikova

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Overview

This study compares linear and circular RNA vaccines against M. tuberculosis, finding notable differences in immunogenicity and efficacy.

Key Points

  • Immunization with linear RNA vaccines resulted in a weaker immune response than BCG vaccination.
  • Both mRNA and BCG significantly reduced bacterial load in mice, suggesting effective infection control.
  • Circular RNA vaccines developed only a humoral immune response without effective protection against infection.
  • The study highlights the potential of mRNA vaccine formulations while underscoring the limitations of circular RNA vaccines.

Cite This Study

Kirshina et al. (2025) studied this question.

synapsesocial.com/papers/68d44c5531b076d99fa562f1https://doi.org/10.24075/brsmu.2025.040
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