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March 5, 2026Molecular Genetics and Genomics1 citationsOpen Access

Advances in Functional Transcriptome Analysis of Mycobacterium Tuberculosis

Advances in functional transcriptome analysis of Mycobacterium tuberculosis: a review

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Authors

KSKarthikeyan SundaramRSRathinam Sridhar

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Overview

This review evaluates novel mRNA and small RNA functions in Mycobacterium tuberculosis, suggesting therapeutic advancements.

Key Points

  • The aim is to evaluate the role of mRNA and various small RNAs in the regulation and progression of Mycobacterium tuberculosis.
  • Reviewed functions of mRNA and small RNAs in Mycobacterium tuberculosis
  • Analyzed gene expression levels of CXCL10, CXCL9, IL1B, and PLA2G2D
  • Investigated IgG responses to m-ESAT6 and m-EsxI
  • Explored the potential of mRNA-based vaccines and therapies
  • Higher mRNA expression levels of specific genes in the tuberculosis group compared to controls
  • Increased IgG levels induced by EspC, MetE, and PPE15
  • mRNA therapy effectively inhibited both Mycobacterium avium and Mycobacterium tuberculosis
  • mRNA vaccines offer therapeutic advantages post-BCG treatment

Cite This Study

Sundaram et al. (2026) studied this question.

synapsesocial.com/papers/69a91db5d6127c7a504c0c75https://doi.org/10.1007/s00438-026-02374-7
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Also Consider

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  5. 5Design and validation of multi-stage expressing mRNA vaccine for Mycobacterium tuberculosis through computational technology2025 · 1 citations