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September 12, 2025ChemistrySelect

Catalyst‐Free Synthesis of Quinazolinone‐Fused Quinoxaline Derivatives under Mild Conditions: Characterization, In Silico Prediction and Biological Evaluation

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Authors

VRVenkadachalam RahimiyaPeriyar UniversityMKMahesh KalidasanSwami Vivekanand College of PharmacyKSKrishnamoorthy Bellie SundaramPSG INSTITUTE OF TECHNOLOGY AND APPLIED RESEARCH

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Overview

This research demonstrates the synthesis of benzoyl indenoquinoxalines and their biological evaluation, suggesting potential as antimicrobial agents.

Key Points

  • Quinoxaline derivatives synthesized showed notable antimicrobial activity against various bacteria, indicating potential therapeutic uses.
  • The reaction produced benzoyl indenoquinoxalines with excellent yields, characterized using FT-IR, NMR, and mass spectrometry.
  • Molecular docking revealed effective binding to human epidermal growth factor receptor tyrosine kinase, supporting the compounds' biological potential.
  • Theoretical DFT calculations complemented experimental findings, enhancing understanding of the compounds' reactivity and behavior.

Cite This Study

Rahimiya et al. (2025) studied this question.

synapsesocial.com/papers/68d44f6931b076d99fa5651bhttps://doi.org/10.1002/slct.202502878
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