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September 12, 2025MoleculesOpen Access

From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications

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Authors

SMSayed H. A. MohamedTanta UniversityYMYehia A.‐G. MahmoudTanta UniversityMBMohamed Y. BediwayTanta University

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Overview

This analysis identifies depsidones in ganoderma lucidum, demonstrating antioxidant effects and anticancer potential, suggesting therapeutic avenues.

Key Points

  • The ethyl acetate extract of ganoderma lucidum showed the highest antioxidant activity and phenolic content, supporting its medicinal potential.
  • Anticancer activity was notable against HepG2, HCT116, MCF7, and A549 cell lines with minimal toxicity to normal Vero cells, indicating a promising safety profile.
  • Nine minor depsidones were identified via UHPLC/Q-TOF-MS/MS analysis, enhancing understanding of the bioactive components in ganoderma lucidum.
  • Strong binding affinities were observed between depsidones and cancer-related targets, highlighting their potential in future drug development.

Cite This Study

Mohamed et al. (2025) studied this question.

synapsesocial.com/papers/68d44f7331b076d99fa56889https://doi.org/10.3390/molecules30173650
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  5. 5In‐Vitro and In‐Silico Insights on Ganodermadiol as Potential Therapeutic for Type 2 Diabetes Mellitus: A Study on Biological Inhibitors From  <i>Ganoderma Lucidum</i>2026