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September 16, 2025European Medical JournalOpen Access

Predicting Prostate Cancer in PI-RADS 1–2 Lesions: The Role of Prostate-Specific Antigen Density, Digital Rectal Examination, and Family History

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Authors

SÖSerkan ÖzcanMDMahamadou DamaKDKürşad Dönmez

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Overview

Retrospective analysis highlights the role of PSA density and family history in detecting prostate cancer in patients with PI-RADS lesions.

Key Points

  • Prostate cancer was detected in 10.5% of patients with PI-RADS 1–2 lesions, indicating a need for improved screening.
  • Higher rates of cancer detection correlated with abnormal digital rectal examination findings and positive family history.
  • Logistic regression showed abnormal DRE and family history as independent predictors of prostate cancer detection.
  • Incorporating clinical factors could enhance biopsy decision-making for patients with low-risk imaging findings.

Cite This Study

Özcan et al. (2025) studied this question.

synapsesocial.com/papers/68d44f7b31b076d99fa56e18https://doi.org/10.33590/emj/jkey1169
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