PSA-density, DRE, and PI-RADS 5: potential surrogates for omitting biopsy?

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1PI-RADS category and biopsy-confirmed clinically significant prostate cancer in a selected Ecuadorian multiparametric MRI cohort: a cross-sectional diagnostic study2026
2. 2Precision in prostate cancer detection: integrating prostate-specific antigen density (PSAD) and the Prostate Imaging Reporting and Data System (PI-RADS) to provide additional risk stratification for a more accurate diagnostic decision2024 · 10 citations
3. 3PI-RADS upgrading as the strongest predictor for the presence of clinically significant prostate cancer in patients with initial PI-RADS-3 lesions2024 · 9 citations
4. 4Predicting Prostate Cancer in PI-RADS 1–2 Lesions: The Role of Prostate-Specific Antigen Density, Digital Rectal Examination, and Family History2025
5. 5To Biopsy or Not Biopsy, That is the Question - PI-Rads 3 Prostate Lesions – Validation of Clinical and Radiological Parameters for Biopsy Decision-Making2025