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September 16, 2025Pediatric ObesityOpen Access

Exposure to Metal Mixtures and Childhood Adiposity: An Examination of Periods of Heightened Susceptibility Between Gestation and Late Childhood

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Authors

JHJanice M. Y. HuMBMichael M. BorgheseMFMandy Fisher

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Overview

This analysis reveals the associations between metal mixtures and adiposity in children, indicating sex-specific effects.

Key Points

  • Third trimester arsenic exposure was linked to increases in zBMI and zWC among females, highlighting susceptibility.
  • Every doubling of third trimester arsenic concentrations resulted in a 0.16 increase in zBMI and 0.13 in zWC for females.
  • Using treed distributed lag mixture models allowed for detailed analysis of metal mixtures and their effects on adiposity.
  • Negative associations were noted between cadmium and waist circumference, suggesting selective impacts of metals in early childhood.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68d44f8331b076d99fa56f65https://doi.org/10.1111/ijpo.70057
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations of Metal Mixtures During Early Pregnancy With Midlife Obesity and Body Composition: A Prospective Study2025
  2. 2Joint Associations of Prenatal Per- and Polyfluoroalkyl Substances and Metal Mixtures with Adiposity in Childhood and Adolescence2026
  3. 3Prenatal and childhood exposure to mixtures of endocrine-disrupting chemicals in association with measures of adiposity in childhood and adolescence2026
  4. 4Prenatal exposure to metal mixtures and the risk of overweight and obesity in school-aged children: insights from metabolomic profiling2026
  5. 5Associations between prenatal metal mixtures and allergic symptoms in childhood2025