Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 17, 2025The Science of The Total EnvironmentOpen Access

Associations between prenatal metal mixtures and allergic symptoms in childhood

View Full Paper
Ask AI
Bookmark
Share

Authors

APAbhishek PandeySMShachi MistryCACecilia Alcalá

Discussion

Loading...

Member takes

Overview

Study reveals prenatal exposure to arsenic and cadmium increases allergic rhinitis risk in children, suggesting the need for screening.

Key Points

  • The aim was to investigate associations between prenatal metal mixtures and allergic symptoms in childhood.
  • Analyzed blood samples from 542 mother-child dyads enrolled in the PROGRESS birth cohort in Mexico City.
  • Examined metal levels during the 2nd and 3rd trimesters, including arsenic, cadmium, copper, and more.
  • Assessed allergic symptoms via questionnaire at ages 4-6 and 6-8 years.
  • Utilized WQS regression modeling for mixture associations with covariate adjustment.
  • Increased risk of allergic rhinitis at age 6-8 linked to 2nd trimester metal mixture (OR = 1.16).
  • Manganese, copper, and lead were significant contributors to the allergic rhinitis risk.
  • Current allergic rhinitis symptoms also associated with 2nd trimester metal exposures (OR = 1.13).
  • 3rd trimester exposures further increased current allergic rhinitis symptoms risk (OR = 1.17).

Cite This Study

Pandey et al. (2025) studied this question.

synapsesocial.com/papers/692509ddc0ce034ddc352260https://doi.org/10.1016/j.scitotenv.2025.180896
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prenatal exposure to metal(loid)s mixture and childhood lung function: Exploring sex-specific associations2025
  2. 2Maternal early-pregnancy and newborn biomarkers of prenatal exposure to Hg, Mn, Se and Zn and child neurobehavioral development in the first 24 months: A prospective cohort study2026
  3. 3Associations of exposure to cotinine, polycyclic aromatic hydrocarbon, and metal(loid) mixtures during pregnancy with birth weight: the MIEHR study2026 · 1 citations
  4. 4Exposure to Metal Mixtures and Childhood Adiposity: An Examination of Periods of Heightened Susceptibility Between Gestation and Late Childhood2025 · 4 citations
  5. 5Association of Prenatal Serum Heavy Metals Exposure with Adverse Birth Outcomes: A Prospective Study2024