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This study investigates the combined influence of maternal and newborn metal exposures on early child neurodevelopment during the first 24 months.

Maternal early-pregnancy and newborn biomarkers of prenatal exposure to Hg, Mn, Se and Zn and child neurobehavioral development in the first 24 months: A prospective cohort study

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Prospective cohort study finds maternal and newborn metal exposure adversely impacts child neurobehavioral development.

This study investigates the combined influence of maternal and newborn metal exposures on early child neurodevelopment during the first 24 months.
Included 2771 mother-infant pairs from the Shanghai Birth Cohort.
Measured maternal early pregnancy blood and newborn cord blood concentrations of Hg, Mn, Se, and Zn.
Assessed neurobehavior using ASQ-3 and BSID-III at ages 6 and 24 months, respectively.
High maternal Hg (> 2.09 μg/L) linked with 1.25 lower communication scores at 6 months (95% CI: -2.11, -0.38).
High maternal Zn (> 5.62 μg/L) associated with 2.66 higher cognition scores at 24 months (95% CI 0.43, 4.89).
Overall metal exposure negatively impacted communication and social-emotional scores at age 6 months.

Zhang et al. (2026) studied this question.

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