Diagnostic Value of MRI Adenohypophysis Volume in Correlation with IGF-1 and IGFBP-3 in Adolescents Growth Disorders

Motivation: Understanding the pituitary gland role in pre-pubertal growth and adolescent, as abnormalities in hormone levels can cause developmental issues. Goal(s): This study aimed to measure pituitary volume using the 3D CUBE MRI technique and assess its correlation with serum levels of IGF-1, IGFBP-3, and GH. Approach: 380 children aged 3-12 underwent serum hormone analysis and MRI scans to quantify adenohypophysis volume and height. Results: Adenohypophysis volume (aPV) correlates strongly with IGF-1 (r = 0.609) and IGFBP-3 (r = 0.560), while growth hormone (GH) has a weak association (r = 0.083). Age, height, and weight significantly influence these relationships, with no impact from gender. Impact: This research highlights the 3D CUBE MRI technique's potential to non-invasively assess pituitary morphology and its hormonal associations, providing valuable insights for pediatric endocrinology and enhancing diagnostic strategies while reducing reliance on contrast agents and associated procedural risks.