September 16, 2025CureusOpen Access

Prognostic Utility of Prothrombin Time-International Normalized Ratio, Interleukin-6, and High-Density Lipoprotein Levels in Patients With Severe Sepsis

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Discussion

Observational study correlates biomarkers of coagulation and inflammation with mortality in sepsis, suggesting improved prognostic accuracy.

A multi-marker approach using IL-6, PT-INR, and HDL enhances prognostic accuracy for mortality in severe sepsis.
Patients who did not survive had higher levels of IL-6 and PT-INR, indicating worse outcomes compared to survivors.
ROC curve analysis demonstrated IL-6 as an exceptional predictor of mortality with 100% sensitivity at a defined cutoff.
Implementing these biomarkers can significantly improve risk stratification and treatment decisions in resource-limited settings.

Kurmana et al. (2025) studied this question.

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Observational study correlates biomarkers of coagulation and inflammation with mortality in sepsis, suggesting improved prognostic accuracy.