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This study aims to assess the prognostic value of interleukin-6 levels at ICU admission for mortality risk in sepsis and septic shock patients.

May 6, 2026BiomedicinesOpen Access

Baseline Interleukin-6 in Sepsis: Mortality Risk Stratification and Survival Analysis in a Prospective Cohort

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Prospective study evaluates interleukin-6's role in mortality risk stratification in sepsis patients, suggesting early risk use.

This study aims to assess the prognostic value of interleukin-6 levels at ICU admission for mortality risk in sepsis and septic shock patients.
Prospective observational study with adult sepsis patients admitted to ICU between 2021 and 2025
ROC curve analysis, Kaplan–Meier survival analysis, and Cox proportional hazards regression used for evaluation
Sample size included adult patients with sepsis and septic shock
IL-6 demonstrated excellent discrimination for in-hospital mortality (AUC = 0.956; 95% CI: 0.893–0.987; p < 0.0001)
Optimal cut-off for IL-6 >135.14 pg/mL yielded sensitivity of 87.65% and specificity of 92.86%
Cox regression analysis showed no significant association between IL-6 levels and time-to-death.

Terteşş et al. (2026) studied this question.

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