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September 16, 2025European PsychiatryOpen Access

Negative Symptoms of Schizophrenia: Contribution of IL-1β, IL-4, and IL-10 Gene Polymorphisms and Adverse Childhood Experiences

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Authors

VMV. A. MikhailovaVGV. GolimbetMAM. Alfimova

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Overview

The analysis reveals links between interleukin gene variants and severity of negative symptoms, suggesting genetic influence from inflammatory responses.

Key Points

  • More severe negative symptoms were found in patients with high-expressive IL-1β and low-expressive IL-4 and IL-10 alleles.
  • Differentiated associations for negative symptom factors were identified for IL-10 rs1800872, highlighting unique genetic influences.
  • Adverse childhood experiences combined with specific gene variants may trend towards increased expression disorder scores.
  • The study underscores the role of cytokine imbalance in the heterogeneity of negative symptoms of schizophrenia.

Cite This Study

Mikhailova et al. (2025) studied this question.

synapsesocial.com/papers/68d4507331b076d99fa57a8ahttps://doi.org/10.1192/j.eurpsy.2025.2218
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Also Consider

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  1. 1The polymorphism ZNF804A rs1344706 is differentially associated with negative symptoms domains in schizophrenia2024
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  3. 3The role of the rs1800795 polymorphism of the interleukin 6 gene in the development of cognitive deficits associated with schizophrenia2025
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  5. 5A Dual-Marker Peripheral Signature of IL-6 Elevation and <i>NEAT1</i> Reduction in Negative-Symptom Schizophrenia: A Cross-Sectional Study2026