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November 19, 2025S S Korsakov Journal of Neurology and Psychiatry

The role of the rs1800795 polymorphism of the interleukin 6 gene in the development of cognitive deficits associated with schizophrenia

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Authors

MAM. V. AlfimovaMGM. V. GabaevaTLT. V. Lezheiko

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Overview

Analysis reveals cognitive deficits relate to IL6 gene polymorphism and adverse childhood experiences in schizophrenia patients.

Key Points

  • This research evaluates the impact of the rs1800795 polymorphism in the IL6 gene on cognitive deficits in schizophrenia.
  • Sample included 530 patients aged 18-45 diagnosed with schizophrenia or related disorders.
  • Participants underwent cognitive testing for processing speed and memory functions.
  • Genotyping at the rs1800795 site of the IL6 gene was performed for each patient.
  • Data on adverse childhood experiences and cognitive premorbid levels were reviewed.
  • Interaction of genotype, adverse childhood experiences, and gender significantly impacted cognitive functioning.
  • Women with ACEs showed lower cognitive performance when carrying the C allele compared to GG homozygotes.
  • Improved understanding of the IL6 gene's role in cognitive deficit among schizophrenia patients.

Cite This Study

Alfimova et al. (2025) studied this question.

synapsesocial.com/papers/6924fed8c0ce034ddc351145https://doi.org/10.17116/jnevro2025125101113
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