Key result
The IL-6R A-allele was associated with an increased prevalence of metabolic syndrome (18.1%, 21.5%, and 25.2% for CC, AC, and AA genotypes, respectively; P=0.010).
Why the study?
Do IL-6 and IL-6R gene polymorphisms modulate IL-6 levels and the prevalence of metabolic syndrome in older Chinese subjects?
Cohort (n=1,979)
Do IL-6 and IL-6R gene polymorphisms modulate IL-6 levels and the prevalence of metabolic syndrome in older Chinese subjects?
Absolute Event Rate: 25.2% vs 18.1%
p-value: p=0.010
The IL-6R rs8192284 SNP is an independent predictor of metabolic syndrome in older Chinese subjects, potentially by modulating IL-6 levels.
No takes yet. Share an insight, caveat, or question.
IL-6R A-allele link to metabolic syndrome is hypothesis-generating; prospective studies needed to assess causality and clinical utility in older Chinese adults.
Jiang et al. (2010) conducted a cohort in Metabolic syndrome (n=1,979). IL-6R (rs8192284-A/C) SNP vs. IL-6R CC genotype was evaluated on Prevalence of metabolic syndrome (p=0.010). The IL-6R A-allele was associated with an increased prevalence of metabolic syndrome (18.1%, 21.5%, and 25.2% for CC, AC, and AA genotypes, respectively; P=0.010).
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