Key result
Plasma IL-6 levels were significantly higher in male schizophrenia patients with metabolic syndrome on second-generation antipsychotics compared to those without metabolic syndrome (P=0.012).
Why the study?
Second-generation antipsychotics frequently cause metabolic syndrome, and inflammatory pathways may contribute to metabolic syndrome and cognitive impairment, prompting investigation into their relationship with IL-6 in this population.
Comparison
Patients with MetS vs non-MetS
Design
Cross-sectional study
Authors
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May support targeted IL-6 assessment in males; leaves open causal role in SGA-related metabolic syndrome.
Cross-Sectional (n=174)
p-value: p=0.019
In schizophrenia patients treated with second-generation antipsychotics, metabolic syndrome is associated with higher IL-6 levels in males, suggesting a gender-specific immune-inflammatory mechanism.
Fang et al. (2019) conducted a cross-sectional in Schizophrenia (n=174). Metabolic syndrome vs. Non-metabolic syndrome was evaluated on Plasma IL-6 levels (p=0.019). Plasma IL-6 levels were significantly higher in male schizophrenia patients with metabolic syndrome on second-generation antipsychotics compared to those without metabolic syndrome (P=0.012).
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