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September 16, 2025European PsychiatryOpen Access

Clozapine response in patients with treatment-resistant schizophrenia: a preliminary report

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Authors

ZMZinovia MaridakiNational and Kapodistrian University of AthensLMLeonidas MantonakisNational and Kapodistrian University of AthensEVEfthimios VasilopoulosNational and Kapodistrian University of Athens

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Overview

Prospective cohort study evaluates clozapine response in treatment-resistant schizophrenia patients, suggesting clinical implications.

Key Points

  • 50% of treatment-resistant schizophrenia patients demonstrated significant clinical response to clozapine, indicating its effectiveness.
  • Baseline assessments using PANSS and PSP scores did not predict clozapine response, suggesting the need for further research.
  • Clinical assessments were performed on 26 eligible patients over 6 months, highlighting the importance of timely clozapine initiation.
  • A significant number of patients were prescribed multiple antipsychotics before clozapine, indicating delays in appropriate treatment.

Cite This Study

Maridaki et al. (2025) studied this question.

synapsesocial.com/papers/68d4507331b076d99fa57b2fhttps://doi.org/10.1192/j.eurpsy.2025.2090
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Demographic and clinical variables associated with response to clozapine in schizophrenia: a systematic review and meta-analysis2021 · 44 citations
  2. 2Retrospective evaluation of sociodemographic and clinical characteristics of patients with schizophrenia receiving clozapine monotherapy and clozapine combined with different antipsychotics2024
  3. 3Predictors of clozapine efficacy in treatment-resistant schizophrenia: A cross-sectional analysis of sociodemographic, clinical, biochemical, and electrophysiological EEG changes2024 · 2 citations
  4. 4Neural substrates of treatment-resistant schizophrenia and the response to clozapine: A structural MRI study in a clinical setting2026
  5. 5The Superiority of Clozapine Over Second-Generation Antipsychotics in Patients With Treatment-Resistant Schizophrenia2025 · 1 citations